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Another small study suggests that HFR could alleviate the pruritus associated with CKD,78 a symptom that has a negative impact on quality of life.79 There is a lack studies that specifically compared the mortality associated with HFR with respect to other HD modalities,80 so it is still unknown whether the previously mentioned benefits of the technique on the inflammatory and nutritional status of patients are translated into increased survival

In addition, we used the following genetically engineered mouse strains from the Jackson Laboratory: Rosa26 mT/mG (RRID:IMSR_JAX:007676) 83 , Rosa26 M2rtTA /TetO-H2BGFP mice 84 , doubly transgenic for a reverse tetracycline-controlled transactivator (rtTA-M2) targeted to the Rosa26 locus and a HIST1H2BJ/EGFP fusion protein (H2BGFP) expressed from a tetracycline promoter element (RRID:IMSR_JAX:005104) 24,85 , multicolor reporter line Rosa26 tm1(CAG-Brainbow2.1)Cle ( R26-confetti , RRID:IMSR_JAX:017492) 86 Rosa26 flYFP/flYFP mice (R26-YFP, RRID:IMSR_JAX:006148) 87 , Rosa26 nT/nG (RRID:IMSR_JAX:023035), Nfe2l2 tm1Ywk (RRID:IMSR_JAX:017009), Rosa26 Cas9-P2A-EGFP (RRID:IMSR_JAX:024858) 63 , Notch1 fl/fl (RRID:IMSR_JAX:007181) 88 , LSL Kras +/ G12D (RRID:IMSR_JAX:019104) 83 and Rosa26 flDNM-GFP/wt (RRID:IMSR_JAX:032613 R26-DNM ) 60,89

None of that evidence, though, separates the technique from its aftercare, because the procedure opens a door, and what happens next is what decides whether the result is the smooth, even skin you wanted or a flare of irritation and pigment you did not

Ma X, McKeen T, Zhang J, Ding WX